Dual inhibition of thrombin and activated factor X attenuates disseminated intravascular coagulation and protects organ function in a baboon model of severe Gram-negative sepsis

BACKGROUND: Inhibition of procoagulant pathways may improve outcome in sepsis. We examined whether a dual short-acting thrombin (factor II) and factor X (FX)a inhibitor (SATI) ameliorates sepsis-induced disseminated intravascular coagulation (DIC) and is organ-protective. METHODS: Escherichia coli w...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Crit Care
Egile Nagusiak: Schöchl, Herbert, van Griensven, Martijn, Heitmeier, Stefan, Laux, Volker, Kipman, Ulrike, Roodt, Jan, Bahrami, Soheyl, Redl, Heinz
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BioMed Central 2017
Gaiak:
Research
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5348796/
https://ncbi.nlm.nih.gov/pubmed/28288667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13054-017-1636-y
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