Dual inhibition of thrombin and activated factor X attenuates disseminated intravascular coagulation and protects organ function in a baboon model of severe Gram-negative sepsis

BACKGROUND: Inhibition of procoagulant pathways may improve outcome in sepsis. We examined whether a dual short-acting thrombin (factor II) and factor X (FX)a inhibitor (SATI) ameliorates sepsis-induced disseminated intravascular coagulation (DIC) and is organ-protective. METHODS: Escherichia coli w...

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Publicat a:Crit Care
Autors principals: Schöchl, Herbert, van Griensven, Martijn, Heitmeier, Stefan, Laux, Volker, Kipman, Ulrike, Roodt, Jan, Bahrami, Soheyl, Redl, Heinz
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2017
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5348796/
https://ncbi.nlm.nih.gov/pubmed/28288667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13054-017-1636-y
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