Dermal phospho-alpha-synuclein deposits confirm REM sleep behaviour disorder as prodromal Parkinson’s disease

Phosphorylated alpha-synuclein (p-alpha-syn) deposits, one of the neuropathological hallmarks of Parkinson’s disease (PD), have recently been detected in dermal nerve fibres in PD patients with good specificity and sensitivity. Here, we studied whether p-alpha-syn may serve as a biomarker in patient...

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Veröffentlicht in:Acta Neuropathol
Hauptverfasser: Doppler, Kathrin, Jentschke, Hanna-Maria, Schulmeyer, Lena, Vadasz, David, Janzen, Annette, Luster, Markus, Höffken, Helmut, Mayer, Geert, Brumberg, Joachim, Booij, Jan, Musacchio, Thomas, Klebe, Stephan, Sittig-Wiegand, Elisabeth, Volkmann, Jens, Sommer, Claudia, Oertel, Wolfgang H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer Berlin Heidelberg 2017
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Original Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5348554/
https://ncbi.nlm.nih.gov/pubmed/28180961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-017-1684-z
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