Tuftsin prevents the negative immunoregulation of neuropilin-1(high)CD4(+)CD25(+)Regulatory T cells and improves survival rate in septic mice

Our previous research showed that neuropilin (Nrp) -1(high)CD4(+)CD25(+)Regulatory T cells (Tregs) exhibited primary negative immunoregulation in sepsis induced immune dysfunction. Tuftsin is the typical ligand of Nrp-1. Herein, we investigated the potential therapeutic value and mechanisms of tufts...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Gao, Yu-Lei, Yu, Mu-Ming, Shou, Song-Tao, Yao, Ying, Liu, Yan-Cun, Wang, Li-Jun, Lu, Bin, Chai, Yan-Fen
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5348430/
https://ncbi.nlm.nih.gov/pubmed/27835904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13235
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