Karyotypic complexity rather than chromosome 8 abnormalities aggravates the outcome of chronic lymphocytic leukemia patients with TP53 aberrations

Patients with chronic lymphocytic leukemia (CLL) harboring TP53 aberrations (TP53abs; chromosome 17p deletion and/or TP53 mutation) exhibit an unfavorable clinical outcome. Chromosome 8 abnormalities, namely losses of 8p (8p−) and gains of 8q (8q+) have been suggested to aggravate the outcome of pat...

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Publicat a:Oncotarget
Autors principals: Blanco, Gonzalo, Puiggros, Anna, Baliakas, Panagiotis, Athanasiadou, Anastasia, García-Malo, MªDolores, Collado, Rosa, Xochelli, Aliki, Rodríguez-Rivera, María, Ortega, Margarita, Calasanz, Mª José, Luño, Elisa, Vargas, MªTeresa, Grau, Javier, Martínez-Laperche, Carolina, Valiente, Alberto, Cervera, José, Anagnostopoulos, Achilles, Gimeno, Eva, Abella, Eugènia, Stalika, Evangelia, Hernández-Rivas, Jesús Mª, Ortuño, Francisco José, Robles, Diego, Ferrer, Ana, Ivars, David, González, Marcos, Bosch, Francesc, Abrisqueta, Pau, Stamatopoulos, Kostas, Espinet, Blanca
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2016
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5348364/
https://ncbi.nlm.nih.gov/pubmed/27821812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13106
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