TRAIL induces pro-apoptotic crosstalk between the TRAIL-receptor signaling pathway and TrkAIII in SH-SY5Y cells, unveiling a potential therapeutic “Achilles heel” for the TrkAIII oncoprotein in neuroblastoma

TrkAIII expression in neuroblastoma (NB) associates with advanced stage disease, worse prognosis, post therapeutic relapse, and in NB models TrkAIII exhibits oncogenic activity and promotes chemotherapeutic-resistance. Here, we report a potential therapeutic “Achilles heel” for the TrkAIII oncoprote...

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Bibliografiska uppgifter
I publikationen:Oncotarget
Huvudupphovsmän: Gneo, Luciana, Ruggeri, Pierdomenico, Cappabianca, Lucia, Farina, Antonietta Rosella, Ianni, Natalia Di, Mackay, Andrew Reay
Materialtyp: Artigo
Språk:Inglês
Publicerad: Impact Journals LLC 2016
Ämnen:
Research Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5348358/
https://ncbi.nlm.nih.gov/pubmed/27821809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13098
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