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Targeting GLI by GANT61 involves mechanisms dependent on inhibition of both transcription and DNA licensing
The GLI genes are transcription factors and in cancers are oncogenes, aberrantly and constitutively activated. GANT61, a specific GLI inhibitor, has induced extensive cytotoxicity in human models of colon cancer. The FOXM1 promoter was determined to be a transcriptional target of GLI1. In HT29 cells...
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| Publicat a: | Oncotarget |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Impact Journals LLC
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5348313/ https://ncbi.nlm.nih.gov/pubmed/27863397 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13376 |
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