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BRAF signals to pro-apoptotic BIM to enhance AraC cytotoxicity induced in AML cells by Vitamin D-based differentiation agents

Vitamin D has so far not fulfilled its early promise as an antineoplastic agent, in spite of compelling in vitro data. With the aim of bringing vitamin D or its derivatives (VDDs) effectively to the clinic, we developed a two-pronged approach. First, by adding the plant-derived Carnosic Acid (CA) to...

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Detalhes bibliográficos
Publicado no:J Steroid Biochem Mol Biol
Main Authors: Wang, Xuening, Harrison, Jonathan S, Studzinski, George P
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5348281/
https://ncbi.nlm.nih.gov/pubmed/27637326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsbmb.2016.09.009
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