Bisdemethoxycurcumin exerts pro-apoptotic effects in human pancreatic adenocarcinoma cells through mitochondrial dysfunction and a GRP78-dependent pathway

Pancreatic cancer is a highly aggressive malignancy, which is intrinsically resistant to current chemotherapies. Herein, we investigate whether bisdemethoxycurcumin (BDMC), a derivative of curcumin, potentiates gemcitabine in human pancreatic cancer cells. The result suggests that BDMC sensitizes ge...

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Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: Yang, Haopeng, Fan, Shengjun, An, Yu, Wang, Xin, Pan, Yan, Xiaokaiti, Yilixiati, Duan, Jianhui, Li, Xin, Tie, Lu, Ye, Min, Li, Xuejun
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2016
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5347794/
https://ncbi.nlm.nih.gov/pubmed/27845899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13272
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