SCIB1, a huIgG1 antibody DNA vaccination, combined with PD-1 blockade induced efficient therapy of poorly immunogenic tumors

PURPOSE: We have previously shown that supraoptimal signaling of high avidity T cells leads to high expression of PD-1 and inhibition of proliferation. This study was designed to see if this effect could be mitigated by combining a vaccine that stimulates high avidity T cells with PD-1 blockade. EXP...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Xue, Wei, Brentville, Victoria A., Symonds, Peter, Cook, Katherine W., Yagita, Hideo, Metheringham, Rachael L., Durrant, Lindy G.
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2016
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5347755/
https://ncbi.nlm.nih.gov/pubmed/27825115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13070
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