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High Avidity Cytotoxic T Lymphocytes Can Be Selected into the Memory Pool but They Are Exquisitely Sensitive to Functional Impairment

High avidity cytotoxic T lymphocytes (CTL) are important in viral clearance and anti-tumor immunity, however, mechanisms for their optimal generation and maintenance in vivo remain unclear. Immunizing mice with an antibody-DNA vaccine encoding a single CTL epitope, induces a 100 fold higher avidity...

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Main Authors: Brentville, Victoria A., Metheringham, Rachael L., Gunn, Barbara, Durrant, Lindy G.
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2012
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3400594/
https://ncbi.nlm.nih.gov/pubmed/22829916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0041112
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