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Crystal structure of Aquifex aeolicus σ(N) bound to promoter DNA and the structure of σ(N)-holoenzyme

The bacterial σ factors confer promoter specificity to the RNA polymerase (RNAP). One alternative σ factor, σ(N), is unique in its structure and functional mechanism, forming transcriptionally inactive promoter complexes that require activation by specialized AAA(+) ATPases. We report a 3.4-Å resolu...

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Bibliografische gegevens
Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Campbell, Elizabeth A., Kamath, Shreya, Rajashankar, Kanagalaghatta R., Wu, Mengyu, Darst, Seth A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2017
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5347599/
https://ncbi.nlm.nih.gov/pubmed/28223493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1619464114
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