Effects of Cdh23 single nucleotide substitutions on age-related hearing loss in C57BL/6 and 129S1/Sv mice and comparisons with congenic strains

A single nucleotide variant (SNV) of the cadherin 23 gene (Cdh23(c.753A)), common to many inbred mouse strains, accelerates age-related hearing loss (AHL) and can worsen auditory phenotypes of other mutations. We used homologous recombination in C57BL/6 NJ (B6N) and 129S1/SvImJ (129S1) embryonic ste...

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發表在:Sci Rep
Main Authors: Johnson, Kenneth R., Tian, Cong, Gagnon, Leona H., Jiang, Haiyan, Ding, Dalian, Salvi, Richard
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2017
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5347380/
https://ncbi.nlm.nih.gov/pubmed/28287619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep44450
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