Mapping the Energetic Epitope of an Antibody/Interleukin-23 Interaction with Hydrogen/Deuterium Exchange, Fast Photochemical Oxidation of Proteins Mass Spectrometry, and Alanine Shave Mutagenesis

Epitope mapping the specific residues of an antibody/antigen interaction can be used to support mechanistic interpretation, antibody optimization, and epitope novelty assessment. Thus, there is a strong need for mapping methods, particularly integrative ones. Here we report identification of an ener...

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Publicado no:Anal Chem
Main Authors: Li, Jing, Wei, Hui, Krystek, Stanley R., Bond, Derek, Brender, Ty M., Cohen, Daniel, Feiner, Jena, Hamacher, Nels, Harshman, Johanna, Huang, Richard Y.-C., Julien, Susan H., Lin, Zheng, Moore, Kristina, Mueller, Luciano, Noriega, Claire, Sejwal, Preeti, Sheppard, Paul, Stevens, Brenda, Chen, Guodong, Tymiak, Adrienne A., Gross, Michael L., Schneeweis, Lumelle A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5347259/
https://ncbi.nlm.nih.gov/pubmed/28193005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.6b03058
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