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On the mechanism and biology of cytochrome oxidase inhibition by nitric oxide

The detailed molecular mechanism for the reversible inhibition of mitochondrial respiration by NO has puzzled investigators: The rate constants for the binding of NO and O(2) to the reduced binuclear center Cu(B)/a(3) of cytochrome oxidase (COX) are similar, and NO is able to dissociate slowly from...

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發表在:Proc Natl Acad Sci U S A
Principais autores: Antunes, Fernando, Boveris, Alberto, Cadenas, Enrique
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2004
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在線閱讀:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC534717/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15546991/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0405368101
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