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Roles of copper and a conserved aspartic acid in the autocatalytic hydroxylation of a specific tryptophan residue during cysteine tryptophylquinone biogenesis

The first posttranslational modification step in the biosynthesis of the tryptophan-derived quinone cofactors is the auto-catalytic hydroxylation of a specific Trp residue at the C-7 position on the indole side-chain. Subsequent modifications are catalyzed by modifying enzymes, but the mechanism by...

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Vydáno v:Biochemistry
Hlavní autoři: Williamson, Heather R., Sehanobish, Esha, Shiller, Alan M., Sanchez-Amat, Antonio, Davidson, Victor L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5347147/
https://ncbi.nlm.nih.gov/pubmed/28140566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b01137
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