CD40-signalling abrogates induction of RORγt(+) Treg cells by intestinal CD103(+) DCs and causes fatal colitis

Immune homeostasis in intestinal tissues depends on the generation of regulatory T (Treg) cells. CD103(+) dendritic cells (DCs) acquire microbiota-derived material from the gut lumen for transport to draining lymph nodes and generation of receptor-related orphan γt(+) (RORγt(+)) Helios(−)-induced Tr...

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Pubblicato in:Nat Commun
Autori principali: Barthels, Christian, Ogrinc, Ana, Steyer, Verena, Meier, Stefanie, Simon, Ferdinand, Wimmer, Maria, Blutke, Andreas, Straub, Tobias, Zimber-Strobl, Ursula, Lutgens, Esther, Marconi, Peggy, Ohnmacht, Caspar, Garzetti, Debora, Stecher, Bärbel, Brocker, Thomas
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5347138/
https://ncbi.nlm.nih.gov/pubmed/28276457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14715
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