Preclinical activity of MBM-5 in gastrointestinal cancer by inhibiting NEK2 kinase activity

NEK2 is a conserved mitotic regulator critical for cell cycle progression. Aberrant expression of NEK2 has been found in a variety of human cancers, making it an attractive molecular target for the design of novel anticancer therapeutics. In the present study, we have identified a novel compound MBM...

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Vydáno v:Oncotarget
Hlavní autoři: Fang, Yanfen, Kong, Yannan, Xi, Jianbei, Zhu, Mengli, Zhu, Tong, Jiang, Tongtong, Frett, Brendan, Hu, Wenhao, Li, Hong-yu, Ma, Mingliang, Zhang, Xiongwen
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2016
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5346717/
https://ncbi.nlm.nih.gov/pubmed/27764815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12687
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