Synergistic targeting of Sp1, a critical transcription factor for myeloma cell growth and survival, by panobinostat and proteasome inhibitors

Panobinostat, a pan-deacetylase inhibitor, synergistically elicits cytotoxic activity against myeloma (MM) cells in combination with the proteasome inhibitor bortezomib. Because precise mechanisms for panobinostat's anti-MM action still remain elusive, we aimed to clarify the mechanisms of anti...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Bat-Erdene, Ariunzaya, Miki, Hirokazu, Oda, Asuko, Nakamura, Shingen, Teramachi, Jumpei, Amachi, Ryota, Tenshin, Hirofumi, Hiasa, Masahiro, Iwasa, Masami, Harada, Takeshi, Fujii, Shiro, Sogabe, Kimiko, Kagawa, Kumiko, Yoshida, Sumiko, Endo, Itsuro, Aihara, Kenichi, Abe, Masahiro
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5346698/
https://ncbi.nlm.nih.gov/pubmed/27738323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12594
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