Pretreatment red blood cell total folate is associated with response to pemetrexed in stage IV non-squamous non-small-cell lung cancer

OBJECTIVES: Pemetrexed inhibits folate-dependent enzymes involved in pyrimidine and purine synthesis. Prior studies of genetic variation in these enzymes as predictors of pemetrexed efficacy have yielded inconsistent results. We investigated whether red blood cell (RBC) total folate, a phenotypic ra...

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Detalhes bibliográficos
Publicado no:Clin Lung Cancer
Main Authors: Bagley, Stephen J., Vitale, Steven, Zhang, Suhong, Aggarwal, Charu, Evans, Tracey L., Alley, Evan W., Cohen, Roger B., Langer, Corey J., Blair, Ian A., Vachani, Anil, Whitehead, Alexander S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5346447/
https://ncbi.nlm.nih.gov/pubmed/27863923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cllc.2016.10.010
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