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Dynamics of ARF regulation that control senescence and cancer
ARF is an alternative reading frame product of the INK4a/ARF locus, inactivated in numerous human cancers. ARF is a key regulator of cellular senescence, an irreversible cell growth arrest that suppresses tumor cell growth. It functions by sequestering MDM2 (a p53 E3 ligase) in the nucleolus, thus a...
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| Publicado no: | BMB Rep |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Korean Society for Biochemistry and Molecular Biology
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5346319/ https://ncbi.nlm.nih.gov/pubmed/27470213 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5483/BMBRep.2016.49.11.120 |
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