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Physiological fidelity or model parsimony? The relative performance of reverse-toxicokinetic modeling approaches
BACKGROUND: Physiologically-based toxicokinetic (PBTK) models are often developed to facilitate in vitro to in vivo extrapolation (IVIVE) using a top-down, compartmental approach, favoring architectural simplicity over physiological fidelity despite the lack of general guidelines relating model desi...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | BMC Syst Biol |
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| Κύριοι συγγραφείς: | , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
BioMed Central
2017
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5346271/ https://ncbi.nlm.nih.gov/pubmed/28284215 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12918-017-0407-3 |
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