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Physiological fidelity or model parsimony? The relative performance of reverse-toxicokinetic modeling approaches
BACKGROUND: Physiologically-based toxicokinetic (PBTK) models are often developed to facilitate in vitro to in vivo extrapolation (IVIVE) using a top-down, compartmental approach, favoring architectural simplicity over physiological fidelity despite the lack of general guidelines relating model desi...
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| Publicat a: | BMC Syst Biol |
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| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
BioMed Central
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5346271/ https://ncbi.nlm.nih.gov/pubmed/28284215 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12918-017-0407-3 |
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