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Solution structure of a dsDNA:LNA triplex

We have determined the NMR structure of an intramolecular dsDNA:LNA triplex, where the LNA strand is composed of alternating LNA and DNA nucleotides. The LNA oligonucleotide binds to the dsDNA duplex in the major groove by formation of Hoogsteen hydrogen bonds to the purine strand of the duplex. The...

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Autors principals: Sørensen, Jesper J., Nielsen, Jakob T., Petersen, Michael
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2004
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC534625/
https://ncbi.nlm.nih.gov/pubmed/15550567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh942
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