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A physiological connection between tmRNA and peptidyl-tRNA hydrolase functions in Escherichia coli

The bacterial ssrA gene codes for a dual function RNA, tmRNA, which possesses tRNA-like and mRNA-like regions. The tmRNA appends an oligopeptide tag to the polypeptide on the P-site tRNA by a trans-translation process that rescues ribosomes stalled on the mRNAs and targets the aberrant protein for d...

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Autori principali: Singh, Nongmaithem Sadananda, Varshney, Umesh
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2004
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC534616/
https://ncbi.nlm.nih.gov/pubmed/15547251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh924
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