Identification of residues within the African swine fever virus DP71L protein required for dephosphorylation of translation initiation factor eIF2α and inhibiting activation of pro-apoptotic CHOP

The African swine fever virus DP71L protein recruits protein phosphatase 1 (PP1) to dephosphorylate the translation initiation factor 2α (eIF2α) and avoid shut-off of global protein synthesis and downstream activation of the pro-apoptotic factor CHOP. Residues V16 and F18A were critical for binding...

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Publicado no:Virology
Main Authors: Barber, Claire, Netherton, Chris, Goatley, Lynnette, Moon, Alice, Goodbourn, Steve, Dixon, Linda
Formato: Artigo
Idioma:Inglês
Publicado em: Academic Press 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5346070/
https://ncbi.nlm.nih.gov/pubmed/28189088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2017.02.002
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