The renal phenotype of allopurinol-treated HPRT-deficient mouse

Excess of uric acid is mainly treated with xanthine oxidase (XO) inhibitors, also called uricostatics because they block the conversion of hypoxanthine and xanthine into urate. Normally, accumulation of upstream metabolites is prevented by the hypoxanthine-guanine phosphoribosyltransferase (HPRT) en...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Zennaro, Cristina, Tonon, Federica, Zarattini, Paola, Clai, Milan, Corbelli, Alessandro, Carraro, Michele, Marchetti, Marialaura, Ronda, Luca, Paredi, Gianluca, Rastaldi, Maria Pia, Percudani, Riccardo
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5345830/
https://ncbi.nlm.nih.gov/pubmed/28282408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0173512
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