A novel P53/POMC/Gαs/SASH1 autoregulatory feedback loop activates mutated SASH1 to cause pathologic hyperpigmentation

p53‐Transcriptional‐regulated proteins interact with a large number of other signal transduction pathways in the cell, and a number of positive and negative autoregulatory feedback loops act upon the p53 response. P53 directly controls the POMC/α‐MSH productions induced by ultraviolet (UV) and is as...

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Pubblicato in:J Cell Mol Med
Autori principali: Zhou, Ding'an, Wei, Zhiyun, Kuang, Zhongshu, Luo, Huangchao, Ma, Jiangshu, Zeng, Xing, Wang, Ke, Liu, Beizhong, Gong, Fang, Wang, Jing, Lei, Shanchuan, Wang, Dongsheng, Zeng, Jiawei, Wang, Teng, He, Yong, Yuan, Yongqiang, Dai, Hongying, He, Lin, Xing, Qinghe
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2016
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5345616/
https://ncbi.nlm.nih.gov/pubmed/27885802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.13022
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