Inhibition of matrix metalloproteinase‐9 by a barbiturate‐nitrate hybrid ameliorates dextran sulphate sodium‐induced colitis: effect on inflammation‐related genes

BACKGROUND AND PURPOSE: Matrix metalloproteinase‐9 (MMP‐9) is up‐regulated in ulcerative colitis and implicated in the pathology of the disease. In this study, we have examined the effects of a barbiturate‐based MMP inhibitor incorporating a nitric oxide donor/mimetic group (dinitrate‐barbiturate) o...

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Veröffentlicht in:Br J Pharmacol
Hauptverfasser: O'Sullivan, Shane, Wang, Jun, Pigott, Maria T, Docherty, Neil, Boyle, Noreen, Lis, Samuel Kana, Gilmer, John F, Medina, Carlos
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2017
Schlagworte:
Research Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5345610/
https://ncbi.nlm.nih.gov/pubmed/28079248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13712
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