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Inhibition of matrix metalloproteinase‐9 by a barbiturate‐nitrate hybrid ameliorates dextran sulphate sodium‐induced colitis: effect on inflammation‐related genes
BACKGROUND AND PURPOSE: Matrix metalloproteinase‐9 (MMP‐9) is up‐regulated in ulcerative colitis and implicated in the pathology of the disease. In this study, we have examined the effects of a barbiturate‐based MMP inhibitor incorporating a nitric oxide donor/mimetic group (dinitrate‐barbiturate) o...
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| Publicado no: | Br J Pharmacol |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5345610/ https://ncbi.nlm.nih.gov/pubmed/28079248 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13712 |
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