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Remote hot spots mediate protein substrate recognition for the Cdc25 phosphatase
Cdc25B is a phosphatase that catalyzes the dephosphorylation and activation of the cyclin-dependent kinases, thus driving cell cycle progression. We have identified two residues, R488 and Y497, located >20 Å from the active site, that mediate protein substrate recognition without affecting activi...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC534539/ https://ncbi.nlm.nih.gov/pubmed/15534213 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0407663101 |
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