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Mechanism of Cdc25B phosphatase with the small molecule substrate p-nitrophenyl phosphate from QM/MM-MFEP calculations

Cdc25B is a dual-specificity phosphatase that catalyzes the dephosphorylation of the Cdk2/CycA protein complex. This enzyme is an important regulator of the human cell cycle, and has been identified as a potential anti-cancer target. In general, protein tyrosine phosphatases are thought to bind the...

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Detalhes bibliográficos
Main Authors: Parks, Jerry M., Hu, Hao, Rudolph, Johannes, Yang, Weitao
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2712249/
https://ncbi.nlm.nih.gov/pubmed/19301836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp805137x
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