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Mechanism of Cdc25B phosphatase with the small molecule substrate p-nitrophenyl phosphate from QM/MM-MFEP calculations
Cdc25B is a dual-specificity phosphatase that catalyzes the dephosphorylation of the Cdk2/CycA protein complex. This enzyme is an important regulator of the human cell cycle, and has been identified as a potential anti-cancer target. In general, protein tyrosine phosphatases are thought to bind the...
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| Autores principales: | , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2712249/ https://ncbi.nlm.nih.gov/pubmed/19301836 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp805137x |
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