Tetraspanin 6: a pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments

BACKGROUND: The mechanisms behind Aβ-peptide accumulation in non-familial Alzheimer’s disease (AD) remain elusive. Proteins of the tetraspanin family modulate Aβ production by interacting to γ-secretase. METHODS: We searched for tetraspanins with altered expression in AD brains. The function of the...

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Détails bibliographiques
Publié dans:Mol Neurodegener
Auteurs principaux: Guix, Francesc X., Sannerud, Ragna, Berditchevski, Fedor, Arranz, Amaia M., Horré, Katrien, Snellinx, An, Thathiah, Amantha, Saido, Takaomi, Saito, Takashi, Rajesh, Sundaresan, Overduin, Michael, Kumar-Singh, Samir, Radaelli, Enrico, Corthout, Nikky, Colombelli, Julien, Tosi, Sébastien, Munck, Sebastian, Salas, Isabel H., Annaert, Wim, De Strooper, Bart
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2017
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5345265/
https://ncbi.nlm.nih.gov/pubmed/28279219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-017-0165-0
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