Gain of power of the general regression model compared to Cochran-Armitage Trend tests: simulation study and application to bipolar disorder

BACKGROUND: Most genome-wide association studies assumed an additive model of inheritance which may result in significant loss of power when there is a strong departure from additivity. The General Regression Model (GRM), which allows performing an assumption-free test for association by testing for...

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Bibliographic Details
Published in:BMC Genet
Main Authors: Dizier, Marie-Hélène, Demenais, Florence, Mathieu, Flavie
Format: Artigo
Language:Inglês
Published: BioMed Central 2017
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5345257/
https://ncbi.nlm.nih.gov/pubmed/28283021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12863-017-0486-6
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