Disruption of TWIST1-RELA binding by mutation and competitive inhibition to validate the TWIST1 WR domain as a therapeutic target

BACKGROUND: Most cancer deaths result from tumor cells that have metastasized beyond their tissue of origin, or have developed drug resistance. Across many cancer types, patients with advanced stage disease would benefit from a novel therapy preventing or reversing these changes. To this end, we hav...

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Publicado en:BMC Cancer
Main Authors: Roberts, Cai M., Shahin, Sophia A., Loeza, Joana, Dellinger, Thanh H., Williams, John C., Glackin, Carlotta A.
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2017
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5345230/
https://ncbi.nlm.nih.gov/pubmed/28283022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-017-3169-9
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