PALB2 mutations in BRCA1/2-mutation negative breast and ovarian cancer patients from Poland

BACKGROUND: The PALB2 gene encodes a protein that plays a crucial role in maintaining genomic integrity. Germline inactivating mutations in PALB2 are associated with an increased risk of breast and ovarian cancer. The prevalence and spectrum of recurrent PALB2 germline mutations in breast and ovaria...

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Détails bibliographiques
Publié dans:BMC Med Genomics
Auteurs principaux: Kluska, Anna, Balabas, Aneta, Piatkowska, Magdalena, Czarny, Katarzyna, Paczkowska, Katarzyna, Nowakowska, Dorota, Mikula, Michal, Ostrowski, Jerzy
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2017
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5345197/
https://ncbi.nlm.nih.gov/pubmed/28279176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12920-017-0251-8
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