Dissecting Target Toxic Tissue and Tissue Specific Responses of Irinotecan in Rats Using Metabolomics Approach

As an anticancer agent, irinotecan (CPT-11) has been widely applied in clinical, especially in the treatment of colorectal cancer. However, its clinical use has long been limited by the side effects and potential tissue toxicity. To discriminate the target toxic tissues and dissect the specific resp...

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Dades bibliogràfiques
Publicat a:Front Pharmacol
Autors principals: Yao, Yiran, Zhang, Pei, Wang, Jing, Chen, Jiaqing, Wang, Yong, Huang, Yin, Zhang, Zunjian, Xu, Fengguo
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2017
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5344918/
https://ncbi.nlm.nih.gov/pubmed/28344557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00122
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