Dissecting Target Toxic Tissue and Tissue Specific Responses of Irinotecan in Rats Using Metabolomics Approach

As an anticancer agent, irinotecan (CPT-11) has been widely applied in clinical, especially in the treatment of colorectal cancer. However, its clinical use has long been limited by the side effects and potential tissue toxicity. To discriminate the target toxic tissues and dissect the specific resp...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Yao, Yiran, Zhang, Pei, Wang, Jing, Chen, Jiaqing, Wang, Yong, Huang, Yin, Zhang, Zunjian, Xu, Fengguo
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5344918/
https://ncbi.nlm.nih.gov/pubmed/28344557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00122
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