Targeting KRas-dependent tumor growth, circulating tumor cells and metastasis in vivo by clinically significant miR-193a-3p

KRas is mutated in a significant number of human cancers and so there is an urgent therapeutic need to target KRas signaling. To target KRas in lung cancers we used a systems approach of integrating a genome-wide miRNA screen with patient-derived phospho-proteomic signatures of the KRas downstream p...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Seviour, Elena G., Sehgal, Vasudha, Mishra, Dhruva, Rupaimoole, Rajesha, Rodriguez-Aguayo, Cristian, Lopez-Berestein, Gabriel, Lee, Ju-Seog, Sood, Anil K., Kim, Min P., Mills, Gordon B., Ram, Prahlad T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5344721/
https://ncbi.nlm.nih.gov/pubmed/27669434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2016.308
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