Sarcolipin deletion exacerbates soleus muscle atrophy and weakness in phospholamban overexpressing mice

Sarcolipin (SLN) and phospholamban (PLN) are two small proteins that regulate the sarco(endo)plasmic reticulum Ca(2+)-ATPase pumps. In a recent study, we discovered that Pln overexpression (Pln(OE)) in slow-twitch type I skeletal muscle fibers drastically impaired SERCA function and caused a centron...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Fajardo, Val A., Gamu, Daniel, Mitchell, Andrew, Bloemberg, Darin, Bombardier, Eric, Chambers, Paige J., Bellissimo, Catherine, Quadrilatero, Joe, Tupling, A. Russell
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5344511/
https://ncbi.nlm.nih.gov/pubmed/28278204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0173708
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