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Inhibition of Drp1 protects against senecionine-induced mitochondria-mediated apoptosis in primary hepatocytes and in mice

Pyrrolizidine alkaloids (PAs) are a group of compounds found in various plants and some of them are widely consumed in the world as herbal medicines and food supplements. PAs are potent hepatotoxins that cause irreversible liver injury in animals and humans. However, the mechanisms by which PAs indu...

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Bibliografiska uppgifter
I publikationen:Redox Biol
Huvudupphovsmän: Yang, Xiao, Wang, Hua, Ni, Hong-Min, Xiong, Aizhen, Wang, Zhengtao, Sesaki, Hiromi, Ding, Wen-Xing, Yang, Li
Materialtyp: Artigo
Språk:Inglês
Publicerad: Elsevier 2017
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5344326/
https://ncbi.nlm.nih.gov/pubmed/28282614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2017.02.020
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