Misrouting of v-ATPase subunit V0a1 dysregulates lysosomal acidification in a neurodegenerative lysosomal storage disease model

Defective lysosomal acidification contributes to virtually all lysosomal storage disorders (LSDs) and to common neurodegenerative diseases like Alzheimer's and Parkinson's. Despite its fundamental importance, the mechanism(s) underlying this defect remains unclear. The v-ATPase, a multisub...

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Publicado en:Nat Commun
Autores principales: Bagh, Maria B., Peng, Shiyong, Chandra, Goutam, Zhang, Zhongjian, Singh, Satya P., Pattabiraman, Nagarajan, Liu, Aiyi, Mukherjee, Anil B.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5344305/
https://ncbi.nlm.nih.gov/pubmed/28266544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14612
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