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Misrouting of v-ATPase subunit V0a1 dysregulates lysosomal acidification in a neurodegenerative lysosomal storage disease model

Defective lysosomal acidification contributes to virtually all lysosomal storage disorders (LSDs) and to common neurodegenerative diseases like Alzheimer's and Parkinson's. Despite its fundamental importance, the mechanism(s) underlying this defect remains unclear. The v-ATPase, a multisub...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Bagh, Maria B., Peng, Shiyong, Chandra, Goutam, Zhang, Zhongjian, Singh, Satya P., Pattabiraman, Nagarajan, Liu, Aiyi, Mukherjee, Anil B.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5344305/
https://ncbi.nlm.nih.gov/pubmed/28266544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14612
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