Loss of ERα induces amoeboid-like migration of breast cancer cells by downregulating vinculin

Oestrogen receptor alpha (ERα) is a well-known target of endocrine therapy for ERα-positive breast cancer. ERα-negative cells, which are enriched during endocrine therapy, are associated with metastatic relapse. Here we determine that loss of ERα in the invasive front and in lymph node metastasis in...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Gao, Yuan, Wang, Zhaowei, Hao, Qiang, Li, Weina, Xu, Yujin, Zhang, Juliang, Zhang, Wangqian, Wang, Shuning, Liu, Shuo, Li, Meng, Xue, Xiaochang, Zhang, Wei, Zhang, Cun, Zhang, Yingqi
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5344302/
https://ncbi.nlm.nih.gov/pubmed/28266545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14483
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