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FOXP3 inhibits cancer stem cell self-renewal via transcriptional repression of COX2 in colorectal cancer cells

Colon cancer stem cell (cCSC) is considered as the seed cell of colon cancer initiation and metastasis. Cyclooxygenase-2 (COX2), a downstream target of NFκB, is found to be essential in promoting cancer stem cell renewal. However, how COX2 is dysregulated in cCSCs is largely unknown. In this study,...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Liu, Shuo, Zhang, Cun, Zhang, Kuo, Gao, Yuan, Wang, Zhaowei, Li, Xiaoju, Cheng, Guang, Wang, Shuning, Xue, Xiaochang, Li, Weina, Zhang, Wei, Zhang, Yingqi, Xing, Xianghui, Li, Meng, Hao, Qiang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5546511/
https://ncbi.nlm.nih.gov/pubmed/28591725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17974
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