FOXP3 inhibits cancer stem cell self-renewal via transcriptional repression of COX2 in colorectal cancer cells

Colon cancer stem cell (cCSC) is considered as the seed cell of colon cancer initiation and metastasis. Cyclooxygenase-2 (COX2), a downstream target of NFκB, is found to be essential in promoting cancer stem cell renewal. However, how COX2 is dysregulated in cCSCs is largely unknown. In this study,...

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Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Liu, Shuo, Zhang, Cun, Zhang, Kuo, Gao, Yuan, Wang, Zhaowei, Li, Xiaoju, Cheng, Guang, Wang, Shuning, Xue, Xiaochang, Li, Weina, Zhang, Wei, Zhang, Yingqi, Xing, Xianghui, Li, Meng, Hao, Qiang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2017
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5546511/
https://ncbi.nlm.nih.gov/pubmed/28591725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17974
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