FOXP3 inhibits cancer stem cell self-renewal via transcriptional repression of COX2 in colorectal cancer cells

Colon cancer stem cell (cCSC) is considered as the seed cell of colon cancer initiation and metastasis. Cyclooxygenase-2 (COX2), a downstream target of NFκB, is found to be essential in promoting cancer stem cell renewal. However, how COX2 is dysregulated in cCSCs is largely unknown. In this study,...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Oncotarget
Prif Awduron: Liu, Shuo, Zhang, Cun, Zhang, Kuo, Gao, Yuan, Wang, Zhaowei, Li, Xiaoju, Cheng, Guang, Wang, Shuning, Xue, Xiaochang, Li, Weina, Zhang, Wei, Zhang, Yingqi, Xing, Xianghui, Li, Meng, Hao, Qiang
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Impact Journals LLC 2017
Pynciau:
Research Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5546511/
https://ncbi.nlm.nih.gov/pubmed/28591725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17974
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