High-Level γ-Glutamyl-Hydrolase (GGH) Expression is Linked to Poor Prognosis in ERG Negative Prostate Cancer

γ-glutamyl-hydrolase (GGH) is a ubiquitously-expressed enzyme that regulates intracellular folate metabolism for cell proliferation, DNA synthesis, and repair. Employing GGH immunohistochemistry on a tissue microarray with 12,427 prostate cancers, we found that GGH expression was negative to low in...

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Publicado no:Int J Mol Sci
Main Authors: Melling, Nathaniel, Rashed, Masoud, Schroeder, Cornelia, Hube-Magg, Claudia, Kluth, Martina, Lang, Dagmar, Simon, Ronald, Möller-Koop, Christina, Steurer, Stefan, Sauter, Guido, Jacobsen, Frank, Büscheck, Franziska, Wittmer, Corinna, Clauditz, Till, Krech, Till, Tsourlakis, Maria Christina, Minner, Sarah, Huland, Hartwig, Graefen, Markus, Budäus, Lars, Thederan, Imke, Salomon, Georg, Schlomm, Thorsten, Wilczak, Waldemar
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5343822/
https://ncbi.nlm.nih.gov/pubmed/28146062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms18020286
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