Loss of forebrain MTCH2 decreases mitochondria motility and calcium handling and impairs hippocampal-dependent cognitive functions

Mitochondrial Carrier Homolog 2 (MTCH2) is a novel regulator of mitochondria metabolism, which was recently associated with Alzheimer’s disease. Here we demonstrate that deletion of forebrain MTCH2 increases mitochondria and whole-body energy metabolism, increases locomotor activity, but impairs mot...

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發表在:Sci Rep
Main Authors: Ruggiero, Antonella, Aloni, Etay, Korkotian, Eduard, Zaltsman, Yehudit, Oni-Biton, Efrat, Kuperman, Yael, Tsoory, Michael, Shachnai, Liat, Levin-Zaidman, Smadar, Brenner, Ori, Segal, Menahem, Gross, Atan
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2017
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5343590/
https://ncbi.nlm.nih.gov/pubmed/28276496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep44401
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