Genomic characterisation of Eμ-Myc mouse lymphomas identifies Bcor as a Myc co-operative tumour-suppressor gene

The Eμ-Myc mouse is an extensively used model of MYC driven malignancy; however to date there has only been partial characterization of MYC co-operative mutations leading to spontaneous lymphomagenesis. Here we sequence spontaneously arising Eμ-Myc lymphomas to define transgene architecture, somatic...

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Udgivet i:Nat Commun
Main Authors: Lefebure, Marcus, Tothill, Richard W., Kruse, Elizabeth, Hawkins, Edwin D., Shortt, Jake, Matthews, Geoffrey M., Gregory, Gareth P., Martin, Benjamin P., Kelly, Madison J., Todorovski, Izabela, Doyle, Maria A., Lupat, Richard, Li, Jason, Schroeder, Jan, Wall, Meaghan, Craig, Stuart, Poortinga, Gretchen, Cameron, Don, Bywater, Megan, Kats, Lev, Gearhart, Micah D., Bardwell, Vivian J., Dickins, Ross A., Hannan, Ross D., Papenfuss, Anthony T., Johnstone, Ricky W.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5343491/
https://ncbi.nlm.nih.gov/pubmed/28262675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14581
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