Epilepsy and intellectual disability linked protein Shrm4 interaction with GABA(B)Rs shapes inhibitory neurotransmission

Shrm4, a protein expressed only in polarized tissues, is encoded by the KIAA1202 gene, whose mutations have been linked to epilepsy and intellectual disability. However, a physiological role for Shrm4 in the brain is yet to be established. Here, we report that Shrm4 is localized to synapses where it...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Zapata, Jonathan, Moretto, Edoardo, Hannan, Saad, Murru, Luca, Longatti, Anna, Mazza, Davide, Benedetti, Lorena, Fossati, Matteo, Heise, Christopher, Ponzoni, Luisa, Valnegri, Pamela, Braida, Daniela, Sala, Mariaelvina, Francolini, Maura, Hildebrand, Jeffrey, Kalscheuer, Vera, Fanelli, Francesca, Sala, Carlo, Bettler, Bernhard, Bassani, Silvia, Smart, Trevor G., Passafaro, Maria
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5343488/
https://ncbi.nlm.nih.gov/pubmed/28262662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14536
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